Transfusion (Transplantation)

Which ONE of the following statements regarding an ABO mismatched in myeloablative stem cell transplantation is correct?

a) Does not result in increased red cell transfusion requirements

b) Associated with delayed neutrophil engraftment

c) Associated with increased graft rejection

d) Associated with increased pure red cell aplasia

e) Associated with decreased overall survival

Answer:

d) Associated with increased pure red cell aplasia

Explanation:

In myeloablative transplants, ABO incompatibility is associated with delayed red cell engraftment, pure red cell aplasia, haemolysis and increased red cell transfusion requirements. It does not affect neutrophil engraftment, graft rejection or overall survival.

Reference:

Booth, Garrett S. et al. Clinical Guide to ABO-Incompatible Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplant , Volume 19 , Issue 8 , 1152 - 1158