BOF: Clotting (Anticoagulation)

Which ONE of the following factors has shown to have the strongest association with thrombosis risk in antiphospholipid syndrome?

a) IgG anticardiolipin antibodies

b) IgG anti Β2 glycoprotein-I antibody of IgA isotype detected by ELISA.

c) IgM anticardiolipin antibodies.

d) IgM anti Β2 glycoprotein-I antibody of IgA isotype detected by ELISA.

e) Lupus anticoagulant positive by DRVVT

Answer:

e) Lupus anticoagulant positive by DRVVT

Explanation:

LA positivity has been shown in a systematic literature review to have the strongest association with thrombosis risk compared to anticardiolipin antibodies.

Reference:

Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature.